36 days ago by ouroboros

Racing toward its ultimate goal of being involved in every aspect of biology, the mammalian sirtuin SIRT1 has been the subject of a number of recent papers, each dealing with a different aspect of the protein’s role. (Abstracts are excerpted; ellipses, emphases, and interpolated commentary are mine. ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

57 days ago by ouroboros

In this first entry on Session II, I’ll focus on the non-telomere-related talks from this session: Jan Vijg gave a review of his published data about stochasticity and transcriptional noise in response to aging and damage. He also described some newer analysis suggesting that transcriptional noise i ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

79 days ago by ouroboros

According to a recent study by Lanza et al., endurance exercise increases mitochondrial protein levels, metabolic enzyme activity, and expression of SIRT3 (a sirtuin thought to be involved in longevity assurance). At the organismal level, insulin sensitivity goes up (this is good: insulin resistance ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

84 days ago by ouroboros

Calorie restriction (CR) extends lifespan in most organisms studied, including some of our more distant relatives — e.g. the baker’s brewer’s yeast Saccharomyces cerevisiae. The genetics underlying CR-mediated life extension are currently being worked out (for details, see our earlier piece, Biogero ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

123 days ago by ouroboros

Our understanding of aging in animals owes a great debt to a large body of careful work in a single-celled organism, the brewer’s yeast Saccharomyces cerevisiae. Indeed, as I’ve argued before, yeast is one of the two organisms with the strongest credible claim to have started modern biogerontology. ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

159 days ago by O. O. Awa

To prevent monotony in the stories of my travels across America, I am spicing things up a bit with some more health news. Bottoms up and bon appetit! New research has shown that red wine is not only good for the heart but also for slowing down the aging process! The new buzz word in this regard is " ...

SurfersBrowse – Business,... - surfersbrowse.com · 1 reference

160 days ago by O. O. Awa

Traveling often can be such hard work, don't you think? So, let's just get a little distraction before moving on again; in the form of some important health-related updates in the past week. Did you hear about how another Jamaican beat Asafa Powell's 100 metres sprint world record? That's right, the ...

SurfersBrowse – Business,... - surfersbrowse.com · 1 reference

160 days ago by Markus

The new SIRT1 faq and resource page has been started. If you look at the top left column on any page throughout the site you will see the link. Please feel free to email me with any additional links you feel will suit the site well. http://www.whatissirt1.com/sirt1-faq.html

What is SIRT1? - whatissirt1.com

161 days ago by ouroboros

Once again the booming literature on calorie restriction (CR) has bested me, and I’ve fallen hopelessly behind. Therefore, without comment, I’ll just run through the last month’s abstracts, with a smattering of brief commentary here and there. Each paper deserves its own entry, but we’re just going ...

Ouroboros - ouroboros.wordpress.com · Rank: 19,330 · 82 references

162 days ago by Markus

This site has been created as a resource to learning more about SIRT1. Those of you looking for information regarding medical studies, research reports, related SIRT1 supplements and drugs, have come to the right place. I will treat this site as a Sirt1 FAQ and urge visitors to post or email me with ...

What is SIRT1? - whatissirt1.com